Software Testing and School University Graduate

Resume/CV Template Contact information Name Address Telephone Cell Phone Email Personal information Date of Birth Sex Optional personal information Marital Status Spouse's Name Children Employment history List in chronological order, include position details and dates Work History Academic Positions Research and training Education Include dates, majors, and details of degrees, training and certification High School University Graduate School Post-Doctoral Training Professional qualifications Certifications and Accreditations Computer SkillsAwards – if any Publications – if any Professional memberships – if any Interests Sample academic recommendation letter DATE: 20th August 2010 From Mr. Your professor name Lecturer, Department of Science, Your College, Chennai – 600018, India. | To whom so ever it may concern| Mr. Your name was my student during his undergraduate program. He is intelligent, hardworking and motivated student. His power of assimilation and his ability to grasp new concepts is good. His enthusiasm for work was conspicuous and he is proved himself to be a natural leader.Besides, he is also good in English language skills and has taken part in many debates and other literary activities. He has bagged many prizes in state-level inter collegiate contests. I am very sure that he will put forth all his efforts into any task he confronts. His positive outlook, capability to work with peers and his willingness to learn from his experimental situation bear testimony that he will do very well in this post graduate studies in your renowned institution. I strongly recommend Mr. Your name for admission to the post graduate program of your university.Thanking you, Yours sincerely (Mr. Your Lecturer name) Sample Work recommendation letter DATE: 12th June 2010 From Mr. Your professor name Project leader, Department of IT, Your Employer, Chennai – 600018, India. | To whom so ever it may concern| It is my great pleasure to write a letter of recommendation on behalf of Mr. Your name, for admission into your postgraduate program. I have know Mr. Your name since july 2007 in my capacity as senior HR executive with Your company name PVT LTd. Mr.Your name has exceeded expectations and has out – shined others in his work group. Mr. Your name strong work ethics, his ability to outperform and passion towards service excellence will be a value addition for your program. I am confident that Mr. Your name will be serious and enthusiastic candidate and someday a quiet successful senior level manager or entrepreneur that would be proud to call an alumini. If you need any additional information, please feel free to contact me over the phone or via email. Sincerely YOUR EMPLOYER NAME)| | Statement of purpose guidelines Review your essay by asking yourself the following questions: Are my goals well articulated? Do I explain why I have selected this school and/or program? Do I demonstrate knowledge of the program? D o I include interesting details that prove my claims about myself? Is my tone confident? Do’s & Don’ts Don’ts 1. Please give more importance in writing SOP, most of them takes it very easy 2. Don’t underestimate the length of time it will take to write your statement of purpose 3.Don’t give your SOP work to be done by someone else 4. Don’t include all your activities, just something which is more important is enough 5. Don’t use any particular name of universities; always prepare a general SOP that can be used for many universities 6. Avoid lengthy personal or philosophical discussions unless the instructions specifically ask for them 7. Don’t exceed more than two pages 8. Avoid grammatical or spelling mistakes this will show your carelessness is writing this SOP. Do’s 1. Always prepare a rough draft or outline of topics.Mostly the topics will include professional career goals, academic interests, research experience, pr actical experience, special skill sets and reason for choosing a course 2. Always find the course requirement from the university and stick to the points which are specified by university 3. Emphasize everything from a positive perspective and write in an active voice 4. Demonstrate your skill sets by experience 5. Your essay should be well organised and everything is linked with continuity and focus 6. Pay more attention to first paragraph 7.Ask others to proof read your statement of purpose. Sample Statement of Purpose Glad to introduce myself as Mr. YOUR NAME, a Software Engineer at present, with 5 years of experience in Software Testing, Quality Analysis and Management. My career is my passion, and it holds my fullest devotion, dedication and commitment. I belong to the field of IT Services Management, which had been the dream I had, the obsession in me and the long term desire that had lingered in me for a long while. And finally, when I got into this, I could give nothing from me but the best.To add more value to the same, I have decided with the best thought of doing my Masters Degree from a reputed institution which would give me not only a degree but also a new style of learning with international standards, innovative methods of self-development skills and the ability of survival among the fittest. Hence, I was left with no other ideas and suggestions from experts, other than to join you, the Bolton University, which I believe should shape me and make myself qualifiedly fit for the IT Services Management skills and to the progress in the modern globalized cultures, technology and era.I hold my Under-Graduate degree, B. Sc in Computer Science which I had completed in the period June 2001 to May 2004 from the YOUR University, Tamil Nadu. I pursued my UG Degree in the YOUR College, Rajapalayam. The syllabus covered here gave me immense knowledge on Software Development, Software Building, Software Techniques, Hardware Configurations, Mathematical skills and Personality Development. I was elected to be the Students’ Chairman at my final year 2003-2004 which had inspired me to know more about the management skills.I was an ardent speaker, athlete and player at my college and finally passed out with prominence winning the â€Å"Best Outgoing Student† Award at my final year. As a starting point in my career, I got employed as a Software Test Engineer with the YOUR PLOYER technologies, Chennai during the period June 2004. It was here that my zeal had taken an initial contour. I was poured with surplus opportunities around me to learn, to explore, to build, to experiment, to renovate and to give a shape to myself. I learnt the concepts of IT services practically.I gained buoyancy in myself. And with that hope I moved to Accenture YOUR EMPLOYER Pvt Ltd, Chennai during the period August 2006. I was promoted as a Senior Programmer. From that time until now, I keep on renewing myself to the changes in the technologies, to the new ways novelty, the exciting facts of Software Testing and many more. I got certified with the National Stock Exchange of India in Financial Services and Capital Markets. I got certified with the IBM Services in Rational Functional Tester tool.I got certified with the HP Services in Quality Center – Defect Management tool and the Quick Test Professional tool. I am also certified with the International Software Testing Qualification Board, as a certified Manual Software Tester. I had won the Celebrating Performance Award from Accenture thrice, for having achieved extreme satisfaction levels from the clients, building my technical skills and for the professionalism I depict in my job. But my journey towards success is still a few more miles away.I need to sparkle in my career with a Masters Degree in my relevant field – the Services Management, without which my career would not be fulfilled. For this to occur, I need your help, your support and your guidance. The Bolto n University gives its students a degree with a dignified knowledge of survival amidst the global standards and also makes you learn the professional development skills in creative leadership. I wish to be a part with you to develop myself in many such areas. Therefore, I request you to accept my purpose and make me move ahead in my career with more confidence and venerable knowledge.

Participative Management Essay

In the corporate world, management style has shifted from scientific management to participatory management. While scientific principles of management underlines communication, leadership and participation , participatory management is anchored on the need for quality management, good relationship with the workers, building teams and integrated organizational structures. Research has shown that the following benefits can be accrued from participatory management. Firstly, it can result to the decline in absenteeism and turnover while enhancing attraction and retention of workers since they have a feeling of ownership in the organization. It also promotes effective and efficient conveyance of information between the management and the employee at all levels in the organization. (Yeatts, Hyten, 1998, p. 16). Elsewhere, it makes everyone to feel a stake order in the decision making process. Additionally, it reduces the cases of internal disagreements and wrangles since the workers interact without suspicion and consider each other a brother/sister. Participative management helps to widen the scope of skills of the staff and enhances innovations and designing of efficient ways and procedures for tasks. Finally, it motivates and gives job satisfaction to the workers ((Yeatts, Hyten, 1998, p. 29). On the other hand, participatory management has some demerits that have been evident in organizations which have implemented it. To begin with, most employees do not accept the responsibility of making decision for the organizations and instead they like being told what to do. At the same time, some of the workers are illiterate and not versed with the tasks of the organization hence they require training. Others demand pay if included in decision making. It requires the participation of many people thus making decision making to go slow resulting to inefficiency (Yeatts, Hyten, 1998, p. 37). In conclusion therefore, participatory management is of great benefit to both private and public sectors. It is the best for the newly founded organizations towards struggle for their survival through competitive advantages.

Reaction Paper on the 11th Hour

The film documentary was most likely called the 11th hour to give emphasis to what would become of humanity in the near future. The latest possible moment – we all must work hand-in-hand to make this a favorable possibility for everyone. It is a challenge we would all face today, but in due time we may reap a great harvest for our fellow people if we persevere. In the field of business, the role of this documentary is to give those in the corporate sector as well as those who own small enterprises an in depth look to why corporate social responsibility is important. They are given the opportunity to look back at the past, present and strive for a future that can still be altered. As the film progresses, the issues on global warming, extinction of species, deforestation as well as the slowly disappearing ocean habitats is depicted giving the viewer the chance to think about what he/she ought to do now. These concerns are actually our country’s own, too. Deforestation as a result of illegal logging had played its part in making matters worse for the past few years – floods had devastated lives, no trees to stop it in its tracks. The drought the country is experiencing – a sign of global warming. Polluted bodies of water had driven out the freshness of the fish as well as other aquatic creatures. Even though it has its share of endangered species, the Philippines however, does not have concerns on the extinction of any at the moment. This is most likely because of many other things the government is busy with. But no matter how we look at it, what is happening to the ecosystem around the world is a large outcry to the acts of the past recurring now.

The Accounting Function in Bank Audi Essay Example | Topics and Well Written Essays - 1750 words

The Accounting Function in Bank Audi - Essay Example This helps them to communicate effectively and it makes the employees feel they are on the page. This approach generated loyalty and challenged the employees to make the business a success. Each employee should be offered stock options and given a portion of the profits as an incentive to keep working toward higher customer satisfaction. Motivation and communication are additional ways the CEO could create happy employees. Challenging employees allows him or her to be creative and generate new ideas or product lines that will increase sales and or customer satisfaction. Listening to employees opinions is vital to success. The people who work the frontline of any business will have ideas on how to better the processes. Some companies used an approach uncommon to most CEO's; walking around the store to meet and greet the associates and customers. This approach allowed the consumers the opportunity to tell him how well he or she liked the store and offer suggestions for change. The asso ciates liked this approach because it made him an approachable CEO who was willing to listen to employees and customers. In this report, it is apparent that the company should use strategic planning in order to deal with the issues since it determines the overall direction and goals of the organization. Consequently, strategic planning influences numerous aspects of the organization, including what, In strategic planning, a) Products and services will be provided by the business and how those products and services will be designed b) Organizational design and roles are needed by the organization. c) Performance goals are established for positions throughout the business. d) Board committees should be developed (in the case of corporations. e) Resources are needed to reach those goals, and consequently, how much money is needed to procure those resources -- ultimately, the goals determine the content of various budgets ("Develop strategic plan" 2007). Competition from similar products, changing technology and increasing costs all play their part in putting pressure on firms to keep rethinking and expan ding. Mergers are more and more frequent and many businesses have expanded to become global organizations. But if growth is sometimes the only option it is also very often a risky one. Expansion demands investment of time, money and people and has to be carefully managed to bring the desired returns. Though there is a way to increase the odds of success: simple and effective communication in all directions. Gap Inc. is a leading international specialty retailer offering clothing, accessories and personal care products for men, women, children and babies under the Gap, Banana Republic, Old Navy and Piperlime brand names. Gap brand includes Gap, GapKids, babyGap and gapbody. The company also operates Gap Outlet and Banana Republic Factory Outlet stores. Our world headquarters offices are based in the San Francisco Bay Area and our product design offices are located primarily in New York City, San Francisco and London. We also have offices around the globe to support our store management, distribution and product manufacturing operations (Gap Inc) HistoryAt the heart of Gap's growth is the unique culture that has

Eisenhower and U.S. Policy in Southeast Asia Essay

Eisenhower and U.S. Policy in Southeast Asia - Essay Example Vietnam policy under Eisenhower can be summed up with two headings. First, a reluctance to actively go to war in Vietnam using the full power of the American military attack force, in spite of the fact that Eisenhower acknowledged the Communist threat from China in Southeast Asia. This reluctance created domestic political friction within the Republican Party and cause a split between those who fiercely opposed Communism and favored full-scale war with Vietnam and Eisenhower, who held back for both external and internal reasons.Secondly, Eisenhower’s precedence led future Administrations to the focus on air attacks rather than directing the attack on land forces. Once the U.S. finally invaded militarily, this policy created initial setbacks in the war as the Vietnamese showed their superior land power that later led to the defeat and withdrawal of American forces. Because the Vietnamese were able to hide in the jungles and sustain minimal damage, air attacks were ineffective a nd the policy to send in limited land forces – a policy rooted in the Eisenhower era -- proved unwise because the strength of the Vietnamese was in their guerilla land forces and they would very clearly demonstrate to the Americans – just as they had to the French – that the Vietnamese would not be defeated on land.Eisenhower’s policy on Vietnam is best revealed by two significant events. The first event established the political framework for his policy and that was Eisenhower’s famous domino theory.... Secondly, Eisenhower's precedence led future Administrations to the focus on air attacks rather than directing the strength of the attack on land forces. Once the U.S. finally invaded militarily, this policy created initial setbacks in the war as the Vietnamese showed their superior land power that later led to the defeat and withdrawal of American forces. Because the Vietnamese were able to hide in the jungles and sustain minimal damage, air attacks were ineffective and the policy to send in limited land forces - a policy rooted in the Eisenhower era -- proved unwise because the strength of the Vietnamese was in their guerilla land forces and they would very clearly demonstrate to the Americans - just as they had to the French - that the Vietnamese would not be defeated on land. Eisenhower's policy on Vietnam is best revealed by two significant events. The first event established the political framework for his policy and that was Eisenhower's famous domino theory. The second event that revealed how his policy would be carried out is revealed in the domestic and international debate over U.S. intervention as the French were being defeated at Dienbienphu in 1954. On April 7, 1954, President Eisenhower held a press conference during which he was asked to comment "on the strategic importance of Indochina to the free world" (Williams, et al: 156). The President responded with the analogy of a "falling domino." He said, "You have a row of dominoes set up, you knock over the first one, and what will happen to the last one is the certainty that it will go over very quickly. So you could have a beginning of disintegration that would have the most profound influences." He went on to say, "But when we come to the possible sequence of events, the

The Great Depression Essay Example | Topics and Well Written Essays - 1000 words

The Great Depression - Essay Example The great depression started in the industrialized North America when the stock market exchange on Oct.29, 1929, commonly known to be â€Å"The Black Tuesday† (Nick Taylor-American Made). As at this time, the output fell by 23% losing more than ten billion US dollars. The market decline was due to disparity between the consumption and production sectors. The production power was due, but the consumption rate was wanting. The producers had to credit their products resulting to lack of finance to these companies hence a subsequent drop in the wages and loss of jobs for the employees (Stock, 1997:177). Many banks realized great loses some of which even saw their closure because most of them had heavily invested in market shares. The problem was major in America but it spread to other countries leading to an economic slump due to forged intimate relation that came in between the United States and the European countries to terminate the First World War. Since United States had emer ged as the super power of the First World War, its economic back thrash had effects across the globe. The depression persisted up to 1932 when the then president of USA Herbert Hoover realized that he had a hand to lend to terminate the depression. In his speech president, Hoover underrated the crisis and said that it would ultimately end. He did not realize that he had to supply food to the hunger stricken population in North America. People raised blame over him for the big economic crisis (Young and Young, 2007:55). Hoover was turned down and an election was called where Franklin Delano Roosevelt won by a large margin. After taking over as the president of United States Rosevelt declared a four-day bank holiday meant relief to relief the banks and make them solvent. During the first one hundred days of his reign Roosevelt set good basis too revive the country from depths of desperation. The great depression had adverse effects to the economy as well as the people of United States . The production level dropped greatly as well as the gross domestic product after the recession started. The lack of market for manufactured goods was the main reason for the decline of the production in the United States (Oakes and Kia, 2004:137). The consumers had lost their purchasing power, which was probably due to the effect of the First World War. Most industries had to give their products on credit leaving them with financial crisis. This led to their immediate closure. The collapse of food prices and lack international market for export made farmers lose morale and quit farming. Credit system in bank declined hence most of the depositors had no option but to withdraw their money from the banks. The experience for the Americans worsened in the 1930s when the agriculture sector leveraged due to the decline in the world market for food prices. The depression also led to lack of jobs in the states. Many people had to move from placer to another hoping against hopes to secure j ob in the towns. The teenagers comprised the large proportion for the job seeking population. This desperate large population had constructed their houses in shantytown in the outskirts of towns, which they made from any available material. The desperate farmers migrated to California in hope to find fertile grounds. Their condition was seriously transient. When he came to power, Franklin Roosevelt instilled hope to the States residents .He started the so-called

Quality Management in Business Assignment Example | Topics and Well Written Essays - 3250 words

Quality Management in Business - Assignment Example What is most important is the way in which a business puts arisen issues to bed such that there will not be a repetition of the same issues. The first part of this paper seeks to identify as well as apply strategies to come up with appropriate solutions. Continuously, well performing companies have come up with ways to be much better in their business. Some companies do believe that waste, scrap as well as defects are a mere cost of running a business. To some extent, they are right because this is a cost. However, this cost can and should be avoided give the reason that it is the cost of poor quality. It adds up once and repeatedly in the form of different currencies; Euros, dollars, pounds, and affects the ability of a company to remain profitable as well as the ability to remain in business. It is always advisable to remember that lack of cash happens to be what kills businesses most eventually. Problem solving art is referred as jidoka by the Japanese. The term simply means plain and simply a method that sports a problem as it arises in business, stopping it as well as analyzing the problem and finally spending time in resolving it such that it will not come up again. The thing involves a continuous culture improvement, which ta kes a great leadership and time. Failure to use effective strategies for solving problems for identification, containing as well as elimination of root causes of the problems has a detrimental and massive impact on business stability and performance. It seriously jeopardizes the competitiveness of the business and its existence as well. Errors are usually made in businesses; issues arise. Too many problems may exist, so how does one know the issue to deal with within the many? The best strategy must be put in place to help in diagnosing and eliminating the causes within the myriad of these issues. To start with, one needs to look for the issue carrying the biggest impact. The method

Classical and Romantic Era styles in music Essay

Classical and Romantic Era styles in music - Essay Example The importance of Les Six in the 1920s of France was important not only because of the changes in classical music. There were also attempts to express the political and social changes that were occurring within France and at a global level. France was currently experiencing the political movements of revolution and war, specifically which began to emerge in the late 1800s. The time period which led to more experimentation was after World War I. The general ideology of those that were in France during this time was based on finding a sense of freedom from the past of politics with an understanding of the complexities from the suffering of war as well as the new philosophies based on freedom. This led to the exploratory nature of the music and the new expressions which showed the modern complexity of the time. The war, as well as the corruptions in politics was then able to guide in new philosophies and ideologies into a sense of modernism1. With the changes in politics, were also alte rations in identity among the French culture. This was based on the ideas of nationalism, specifically which expressed a new ideology by understanding that France needed to regain an identity outside of the wars that were being fought. The ideal of patriotism of France, as well as the identity of changing the cultural aspects that were associated with the France became the main objectives. This was combined with the concept of modernity, specifically which came from the growth of the industrial era.

Net Profit Margin as the Sole Performance Measure PowerPoint Presentation

Net Profit Margin as the Sole Performance Measure - PowerPoint Presentation Example The paper tells that a good management structure should be able to efficiently manage expenses and cost in order to increase profit. A company is not well managed if there is a decline in the net profit margin over successive financial periods. It means that it is not using the resources available efficiently. In the case of Integrated Technology Services UK Limited, it was becoming increasingly difficult to meet the 6% Net profit Margin. There were four factors that were found to be the contributing to the increase in overheads. The response was budgetary control and improving financial planning. Net profit margin brings to attention some avoidable or unnecessary costs that gross profit margin (gross profit over revenue as a percentage) may not be able bring out. Net profit margin can be used as a basis of price control. It provides the best benchmark through which to formulate a pricing strategy. Integrated technology Service UK Limited   has a fixed net profit margin of 6% .Cont racts with clients have to be calculated with this net profit margin percentage in consideration. Net profit margin as the sole performance measure has the advantage of being able to detect the company’s net earnings trends. A company that is doing well will have a consistent or increase in net profit margin. This is particularly important when looking for investors. Investors are not only looking for companies that have increasing profit over the years, but a company that is also having its net profit margin increasing over the years. Net profit margin can be used as a measure of a company’s strength.

Li and Fung Limited Essay Example for Free

Li and Fung Limited Essay Ans#1- Li Fung Limited is a global trading group. A company would like to use the supply chain management services of Li Fung because it manages the supply chain for high volume, time sensitive consumer goods, delivering the right location. It focuses on providing a one- stop shop service through a network of 69 sourcing offices in 40 countries. Company would prefer Li Fung rather than organising in-house department or appointing a senior manager to handle these activities because it provides services range from product design , development, through raw material and factory sourcing, production planning and management, quality assurance and on to export documentation and shipping consolidation. Moreover company use Li Fung because it could be an effort to also reduce costs. Ans#2- Li Fung expand its global sourcing network through acquisitions since it has found developing networks from the ground up tends to take a long time and to be relatively expensive. Li Fung acquired companies like Inchcape Buying Services in 1995, Swire Maclaine Ltd , Camberley Enterprises Ltd and Colby Group Holdings Ltd. These all are well established companies. Li Fung company is in favour of acquisitions because it doubled the size of company and expanded the companys customer base in Europe and strengthen its position in the U.S. These acquisitions increased the size of Li Fungs sourcing network from 48 offices in 32 countries in 1999 to 68 offices in 40 countries in 2001. Ans#3- Internet opens the door to new levels of connectedness to customers. Successful firms on the Web have used cyberspace to achieve their objectives. Li Fung use the Internet to capture additional business like small to medium- size -businesses that is characterized by small order size and shorter delivery requirements. But they cannot afford large sum of money in inventory. Internet provides solution to these kind of problems. It could allow Li Fung to consolidate small orders for mass production by existing supplier network. Li Fung allow these smaller businesses to have their own private label. The choices available online would allow a product to have the small businesss own distinctive label attached with choices available online and would choices of embroidery colors and packaging. Li Fung should use search engine optimization for increase the awareness of its website. In order to make the additional businesses profitable Li Fung could use their website www.studiodirect.com in many ways. The studio direct will combine its expertise in sourcing and merchandising of apparel with supply chain efficiency. It will derive from its web- based trading. Studio Direct has outsourced every aspect of delivery from pick and pack, shipping and customer clearance.

Tuberculosis: Prevention and Treatment

Tuberculosis: Prevention and Treatment Tuberculosis (TB) is an airborne infectious disease which is caused by strains of mycobacteria, mainly Mycobacterium tuberculosis1. There are roughly one third of the worlds population are infected with tuberculosis where nine millions of new cases reported annually2. Although tuberculosis can be prevented and treated, it continues to cause millions of deaths every year2. When infected individual coughs, sneezes or spits, M. tuberculosis is propelled into the air and infected those who breathed in the bacteria that existed in droplets of saliva3. Primarily, tuberculosis will affect the lungs, known as pulmonary tuberculosis3. It will also affect other parts of body, for instance lymph nodes, bones, brain and kidneys3. Once a person is infected with tuberculosis, there are basically three possible ways may occur. Firstly, the immune system plays a vital role and strong enough to kill the bacteria3. Secondly, immune system is not strong enough to fight off the bacteria but is able to b uild a defensive barrier against the bacteria3. Individuals who are latently infected with M. tuberculosis show asymptomatic where these bacteria lie dormant in the lungs and able to reactivate after years1. The disease is often reactivated in those who are immunocompromised or generally weakened. Lastly, the immune system fails to kill bacteria causing the bacteria to grow and spread towards other parts of body which is called active tuberculosis3. In the fight of tuberculosis, World Health Organisation (WHO) recommends universal Bacille Calmette-Guà ©rin (BCG) vaccination in the countries with high TB burdens4. BCG vaccine contains weakened form of M. tuberculosis which will induce human antibodies to fight against this type of bacteria. The efficacy of BCG vaccination can be ranging from 0% to 84%5. This may be due to the frequency of TB exposure and quality of vaccine used, leading to arguments on BCG vaccination efficacies4. One of the greatest arguments is that BCG vaccination causing positive reactions to tuberculin skin testing and hence interfere with the diagnosis of latent TB4. Existence of evidences showing the rates of efficacy also depends on geographical location, age at vaccination and form of TB further complicate the situation. Currently, TB chemotherapy is made up of combination of a list of first-line drugs isoniazid (INH), rifampicin (RIF), pyrazinamide (PZA) and ethambutol (EMB) 6. If the treatment fails d ue to bacterial drug resistance, or patient unable to tolerate, second-line drugs for instance para-aminosalicylate (PAS), fluoroquinolones, ethionamide and cycloserine are introduced6. These are considered as second line drugs generally either less potent with larger doses regimen or more toxic with serious side effects6. Tuberculosis is presently treated in two phases, namely initial phase and continuous phase7. In initial phase, the patient will be treated with concurrent use of four first line drugs, with the aim to eradicate or control bacteria population to replicate in rapid motion and also avoid the emergence of bacteria resistance7. The treatment choices available for initial treatment include isoniazid, rifampicin, pyrazinamide and ethambutol7. Streptomycin is used rarely but can be used in patients who infected with bacteria that are resistant to isoniazid before the therapy is commenced7. The duration for initial phase is 2 months whereas the continuous phase takes 4 months7. During the four months of continuous phase, patients are treated with isoniazid and rifampicin at same doses7. Most of the TB treatment is supervised where drug administration needs to be fully supervised by healthcare professions since lengthy duration of treatment causing incompliance in patients7. These patients who are unlikely to be compliance will be given the drugs three times a week until the course is completed while patients who able to comply with the treatment will not be supervised7. Despite the chemotherapy treatment and BCG vaccine, TB remains as a significant infectious disease due to increasing emergence of drug resistant TB and co-infection with Human Immunodeficiency Virus (HIV) 6. Since the host defense in HIV patients is suppressed, they are more susceptible to TB infections. Moreover, drug- drug interactions between antiviral therapy and anti-TB also causing complications in treating co-infected patients6. Drug resistant TB has evolved mainly because of improper treatment or incompliance in patients who stop taking their medications before the bacteria is being fully eradicated since the duration of treatment is lengthy which takes 6-9 months8, 9. The mechanism involved includes chromosomal mutations in genes that responsible for drug targets encoding9. When there is a sequential accumulation of mutations, multi-drug resistant tuberculosis (MDR-TB) emerges where the M. tuberculosis strains will resistant to two of the most commonly used drugs, Isoniazid and Rifampicin9. Patients with MDR-TB are then relying on the second-line drug classes, fluoroquinolones and the three injectable agents namely amikacin, capreomycin, and kanamycin10, 11. The chances to cure would dramatically be reduced for patients who infected with extensively drug-resistant tuberculosis (XDR-TB), a situation where the isolated strains are resistant against any one of fluoroquinolones and at least one of three injectable drugs6. In order to combat with the MDR-TB or XDR-TB and optimize the tuberculosis drug regimen, it is crucial to understand the mechanism of action of current using first-line drugs and how resistance is developed against these drugs. Isoniazid (INH) or isonicotinic acid hydrazide is discovered in 1952, a bactericidal agent which active against organism of the genus Mycobacterium, especially M. tuberculosis, M. bovis and M. kansassi6, 12. In vivo, INH has shown to be bactericidal in culture over the first 48 hours which become bacteriostatic after this particular time frame12. This indicates that INH is bacteriostatic for slow replicating bacilli but is bactericidal against rapidly dividing mycobacterium. The minimal tuberculostatic concentration is 0.025 to 0.05ug/ml13. INH is a prodrug that needs to be activated by catalaseperoxide hemoporotein, KatG before acts by inhibiting mycolic acid synthesis and cell wall disruption in susceptible mycobacterium13, 14. This inhibitory action is only targeted to mycobacteria since other bacteria do not contain mycolic acid in the cell wall13. INH acts by inhibit enoyl acyl carrier protein (ACP) reductase, InhA, and a beta-ketoacyl-ACP synthase, KasA that are crucial in fatt y acid synthesis system for mycolic acid15. Resistance to INH is believed due to mutations in gene encoding catalaseperoxidase katG or InhA or lacking KatG 9, 14. Isoniazid is metabolised in the liver, mainly by acetylation and dehydrazination where slow acetylator may experience higher concentration leads to potential toxicity before excreted in the urine within 24 hours13. Rifampicin (RIF), discovered in 1963, is a lipophilic semisynthetic derivative of rifamycin antibiotic which is produced by the fermentation of a strain of Amycolatopsis mediterranei6, 9, 16. RIF has bactericidal activities against a broad spectrum of microorganisms including gram-positive and gram-negative. RIF will inhibit the action of DNA-dependent RNA polymerase of mycobacteria that is encoded by rpoB through formation of a stable drug-enzyme complex9. This will suppress the initiation chain formation in RNA synthesis and hence prohibit protein synthesis in M. tuberculosis9. Development of resistance to RIF is mostly due to mutation in 81 base pair region of rpoB gene thus facilitate a straightforward approach to detect MDR-TB since 85-90% RIF-resistant strains are also resistant to INH9. RIF produces peak plasma concentration of 7ug/mL in 2 to 4 hours after ingestion of 600mg17. It also distributed well to most of the body tissues and fluids, including cerebrospinal fluid since it is lipophilic17. Following absorption from the gastrointestinal tract, RIF is eliminated rapidly in the bile with fewer amounts excreted through urine17. Pyrazinamde (PZA) is discovered in 1954 and it produces excellent sterility effects against semidormant tubercle bacilli at slightly acidic pH6, 9. The antimicrobial activity of PZA is through interference with mycolic acid synthesis in M. tuberculosis by pyrazinoic acid, an active moiety of PZA9. Conversion of PZA to pyrazinoic acid is mediated by pyrazinamidase enzyme that is encoded by pncA gene in M. tuberculosis, thus indicating that these bacilli are sensitive to PZA9. Resistance against PZA evolved when mutation occur at pncA gene that is responsible for pyrazinamidase, hence affecting the activity of this enzyme9. PZA is well absorbed from gastrointestinal tract and is widely distributed to most tissues and fluid too17. The oral administration of 500 mg PZA produces plasma concentrations of 9-12ug/ml after two hours and 7ug/ml after 8 hours17. PZA is metabolized in liver whereas the metabolites are excreted through renal glomerular filtration17. Ethambutol (EMB) is discovered in 1962, acts as bacteriostatic agent and is active against undergoing cell division6, 18. EMB primarily targets on impairment of cell wall polymerization by inhibits arabinosy transferase, a vital enzyme responsible for mycobacteria cell wall biosynthesis9, 18. Since arabinosy transferase enzyme is encoded by embC-embA-embB genes, resistance against EMB evolved is believed due to mutation of these genes9. EMB is currently used as one of the first-line treatment for tuberculosis mainly because of its synergistic effect with other front-line drugs and its low toxicity property18. There is roughly 75-80% of an oral dose of EMB is rapidly absorbed in gastrointestinal tract with absorption unaffected when administered with foods19. In addition, EMB is distributed widely to body tissues and fluid, including cerebrospinal fluid before being metabolized in the liver and excreted in urine19. Streptomycin (SM) is an aminoglycoside antibiotic, used as first line treatment for TB when it first discovered in 19441, 6. Streptomycin is isolated from the bacteria Streptomyces griseus and its antimicrobial effects against M. tuberculosis is highly effective when use in combination with other first line agents20. However, SM is no longer considered as first line treatment as resistance against it has developed rapidly1. The optimum pH for SM is at pH8 where its bacteriostatic activity will reduce with increasingly acidic environment20. SM acts by binding tightly to A site of 16S ribosomal RNA subunit, interferes with mRNA translation, causing faulty protein being produced1, 9. Resistant emergence when the mutation occurs at gene rpsL and rrs that encoded for 16S and S12 ribosomal protein1, 9. Upon administration, SM is poorly absorbed from gastrointestinal tract and mostly administered parentally1. SM is mostly excreted in urine and patients with low renal profile might experienc e toxicity such as neurotoxic reactions1. When the first line treatment is no longer suitable for patients or patients develop multi-drug resistance TB, second line drugs will then be introduced in combating the TB. Second line drugs that are mostly used include Ethionamide (ETH), Cycloserine (CS), Para-Aminosalicylic Acid (PAS) and Fluoroquinolones (FQ). ETH has been in use since 1960s, is a structural analogue of INH and it targets at inhibition of mycolic acid biosynthesis in tubercle bacilli9, 21. INH however is much more potent than ETH since the minimal inhibitory concentration for ETH is 0.5-5.0ug/mL21. Resistance evolved due to mutation at gene InhA and ethA which encode for oxygenase enzyme in activation of ETH 9. In vitro, CS has inhibitory effect on M. tuberculosis at 5-200ug/mL and there is no cross resistance occurred between CS and other drugs13. CS acts by interfereing the biosynthesis of bacterial cell wall13. CS is well absorbed in gastrointestinal tract and also widely distributed to body tissues and fluid including cerebrospinal fluid13. PAS was first introduced as first line drug but being replaced by Ethambutol in 1960s1. It acts bacteriostatically with possessing inhibitory effect at concentration less than 1mg/ml by interfere with folic acid metabolism in bacteria1. PAS is readily absorbed from gastrointestinal tract and distributed well throughout the body. Approximately 80% of the drugs will be excreted via kidney after being metabolized to acetylated form1. Moxifloxacin and Gatifloxacin are both been synthesized and evaluated as excellent bactericidal agents through inhibiting DNA gyrase, an ATP-dependent enzymes topoisomerase II which is responsible in bacteria DNA transcription9. DNA gyrase is consisted of two subunits that is arranged in a complex, is encoded by two different genes, gyrA and gyrB where mutations at gyrA will normally cause bacteria resistance to these new generation of flouroquinolones9. Due to the increasing incidence of multidrug resistance TB, it is highly desirable to develop new drugs that are not only potent and effective against current resistant strains of M. tuberculosis but also possess shorter treatment duration since most of the incompliance of patients is brought up by lengthy TB treatment. Most of the mechanisms of action of current treatments are involved in interfering the bacterial DNA synthesis, protein and mycolic cell wall biosynthesis. The enzymes that participate in these pathways could also be the target of newly designed drugs such as TMC207, one of the new drugs which are currently under investigations and clinical trials. TMC207 is a member of diarylquinoline class of compound which target at adenosine triphosphate (ATP) synthase by binding to subunit C of the synthase, blocking the energy pathway of mycobacteria22, 23. In vitro, TMC207 not only possesses ability to inhibit both drug sensitive and resistant M. tuberculosis isolates, but also able to sterilize the patient through killing the dormant bacilli bactericidally22. TMC207 showed a minimum inhibitory concentration of 0.03ug/mL against M. tuberculosis, suggesting a more potent agent compared to current first- line treatments such as isoniazid and rifampicin23. Apart from that, its synergistic effect with pyrazinamide could promise as effective drug combination for sterilizing the patients against TB22. A phase I clinical trials which involved short terms administration of TMC207 in healthy individuals showing no adverse effects and the subjects are well tolerated with it23. However, it is essential to investigate the selectivity of TMC207 again st mammalian ATP synthase with longer periods to ensure the patients safety when administered with TMC207. Thiacetazone (TAC) is widely used as second line anti-TB agent against multiresistant tuberculosis at present24. TAC acts by interferes the biosynthesis pathway of mycolic acid in tubercle bacilli24. The fact that M. tuberculosis has been difficult to eradicate and remains persistent is due to its cell wall that composed of mycolic acid which is resistant against chemical injury, dehydration and also has low permeability to antibiotics24. Mycolic acid contains cyclopropane rings that is activated through cyclopropane mycolic acid synthase (CMASs), has a significant contribution to tuberculosis24. By inhibiting the cyclopropanation, the cell wall biosynthesis will then be interrupted, introducing the bactericidal effects24. The aim of this research is to synthesis and evaluates the analogues of Thiacetazone which might be potential anti tuberculosis agents. The analogues will be tested against different strains of mycobacteria in lab. The target actions of these analogues will also be identified based on the structure of the analogues. The above analogue is synthesized when a benzylaldehyde reacts with a primary amine. This is a condensation process and an imine is produced. The changes at position R1 to R3 with different electron withdrawing groups are first planned to be evaluated. However, the plan is prohibited since the corresponding structures are either unavailable or too expensive that falling outside the budget. After revised on the previous analogues that were discovered and their respective MIC values obtained from lab, the structures of new analogues that are going to be evaluated are finally sorted out. The R1 to R3 positions would be replaced by either a -chloro or a -methoxy with R8 position would either be an amine, a methyl or a benzene ring. A chloro is used at position R1 to R3 since it is electron withdrawing, big and lipophilic molecule whereas the methoxy group is electron donating, small and quite lipophilic. For R8 position, an amine is selected because it is electron withdrawing and small. A methyl is also selected since it is quite lipophilic, small and electron donating. On the other hand, benzene ring which is highly lipophilic, neither electron donating nor withdrawing group might have a different effect on the analogue synthesized. References: Patrick Brennan, Douglas Young (2008). Tuberculosis. 88(2), 85-86, 137-138, 162-163. Health Protection Agency. http://www.hpa.org.uk/HPA/ National Health Services. http://www.nhs.uk/Pages/HomePage.aspx Zaida Araujoa, Jacobus Henri de Waard, Carlos Fernà ¡ndez de Larrea, Rafael Borges, Jacinto Convit (2008). The effect of Bacille Calmette-Guà ©rin vaccine on tuberculin reactivity in indigenous children from communities with high prevalence of tuberculosis. Vaccine 26, 5575-5581. Hart and Sutherland (1977). BCG and vole bacillus vaccines in the prevention of tuberculosis in adolescence and early adult life. Br Med J2(6082), 293-295. Global Alliance for TB Drug Development. http://www.tballiance.org/home/home.php 57th edition of British National Formulary: Section on Tuberculosis drugs, 316-317. Blumberg, H. M. et al. (2003). American Thoracic Society/ Centers for Disease and Prevention/ Infectious Disease Society of American: treatment of TB. Am.J.Respir.CareMed.167, 603-662. Suhail Ahmad and Eiman Mokaddas (2009). Recent advances in the diagnosis and treatment of multidrug-resistant tuberculosis. Respiratory Medicine 103(12), 1777-1790. Frieden TR, Sherman LF, Maw KL, et al. (1996). A multi-institutional outbreak of highly drug-resistant tuberculosis: epidemiology and clinical outcomes. JAMA 276, 1229-1235. Mukherjee JS, Rich ML, Socci AR, et al. (2004). Program and principles in treatment od multi-drug resistant tuberculosis. Lancet 363, 474-481. Zhang Y. et al. (2003). Isoniazid. Tuberculosis 2, 739-758. Hardmn, J.G., L.E. Limbird, P.B Molinoff, R.W. Ruddon, A.G. Goodman (2006). Goodman and Gilmans The Pharmacological Basis of Therapeutics. 9, 1164-1165. Zhang Y, Heym B, Allen B, Young D, Cole S (1992). The catalase-peroxidase gene and isoniazid resistance by Mycobacterium Tuberculosis. Nature 358, 591-593. Richard A. Slayden, Richard E. Lee and Clifton E. Barry (2002). Molecular Microbiology 38(3), 514-525. Rup Lal, Sukanya Lal (2005). Recent trends in rifamycin research. BioEssays 16(3), 211-216. Hardmn, J.G., L.E. Limbird, P.B Molinoff, A.G Gilman (2001). Goodman and Gilmans The Pharmacological Basis of Therapeutics. 10, 1278-1281. Raghunandan Yendapally and Richard E. Lee (2008). Design, synthesis and evaluation of novel ethambutol analogues. Bioorganic and Medical chemistry Letters 18(5), 1607-1611. McEvoy, G.K. (2007). Admerican Hospital Formulary Service. Besthesda, 551. Selman A. Waksman (1953). Streptomycin: Background, Isolation, Properties and Utilisation. Science, 118(3062), 259-266. Sampson AE, Barry CE (1999). Abstract General Meeting American Society Microbiology. 99, 635. Andreas H.D., Alexander Pym, Martin Grobusch et al. (2009). The Diarylquinoline TMC207 for Multidrug- Resistant Tuberculosis. 360(23), 2397-2405. Anna C. Haagsma, Rooda Abdillahi-Ibrahim, Marijke J. Wagner, Klaas Krab, Karen Vergauwen, Jerome Guillemont, Koen Andries, Holger Lill, Anil Koul, and Dirk Bald (2009). Selectivity of TMC207 towards mycobacterial ATP synthase compared with that towardsthe Eukaryotic homologue. Antimicrobial Agents and Chemotherapy, 53(3), 1290-1292. Anuradha Alahari, Xavier Trivelli, Yann Guà ©rardel, Lynn G. Dover, Gurdyal S. Besra, James C. Sacchettini, Robert C. Reynolds, Geoffrey D. Coxon, Laurent Kremer (2007). Thiacetazone, an Antitubercular Drug that Inhibits Cyclopropanation of Cell Wall Mycolic Acids in mycobacteria. PloS ONE, 2(12): e1343. Mycolic acids are a complex mixture of branched, long-chain fatty acids, representing key components of the highly hydrophobic mycobacterial cell wall. Pathogenic mycobacteria carry mycolic acid sub-types that contain cyclopropane rings. Double bonds at specific sites on mycolic acid precursors are modified by the action of cyclopropane mycolic acid synthases (CMASs). The latter belong to a family of S-adenosyl-methionine-dependent methyl transferases, of which several have been well studied in Mycobacterium tuberculosis, namely, MmaA1 through A4, PcaA and CmaA2. Cyclopropanated mycolic acids are key factors participating in cell envelope permeability, host immunomodulation and persistence of M. tuberculosis. While several antitubercular agents inhibit mycolic acid synthesis, to date, the CMASs have not been shown to be drug targets. We have employed various complementary approaches to show that the antitubercular drug, thiacetazone (TAC), and its chemical analogues, inhibit mycolic acid cyclopropanation. Dramatic changes in the content and ratio of mycolic acids in the vaccine strain Mycobacterium bovis BCG, as well as in the related pathogenic species Mycobacterium marinum were observed after treatment with the drugs. Combination of thin layer chromatography, mass spectrometry and Nuclear Magnetic Resonance (NMR) analyses of mycolic acids purified from drug-treated mycobacteria showed a significant loss of cyclopropanation in both the ?- and oxygenated mycolate sub-types. Additionally, High-Resolution Magic Angle Spinning (HR-MAS) NMR analyses on whole cells was used to detect cell wall-associated mycolates and to quantify the cyclopropanation status of the cell envelope. Further, overexpression of cmaA2, mmaA2 or pcaA in mycobacteria partially reversed the effects of TAC and its analogue on mycolic acid cyclop ropanation, suggesting that the drugs act directly on CMASs. This is a first report on the mechanism of action of TAC, demonstrating the CMASs as its cellular targets in mycobacteria. The implications of this study may be important for the design of alternative strategies for tuberculosis treatment.

To what extent do the detective fiction stories looked at imitate Essay

To what extent do the detective fiction stories looked at imitate The Murders in the Rue Morgue in terms of the character and the creation of tension? Question: To what extent do the detective fiction stories looked at imitate 'The Murders in the Rue Morgue' in terms of the character and the creation of tension? This essay will explain, discuss and examine the effects of Edgar Allen Poe's 'The Murders in the Rue Morgue' had on other authors writing detective stories during the 19th century. 'The Murders in the Rue Morgue' was a new kind of story and Edgar Allen Poe had many authors imitate him. Take Arthur Conan Doyle's detective, Sherlock Holmes, for example. Holmes quickly became one of the most famous detectives of that time and his stories were, and still are, loved all around the world. But not forgetting all of the other detective writers of that time too. To an extent, most detective stories of the 19th century have copied the original aspects of Poe's 'The Murders in the Rue Morgue.' This essay will examine Poe's influence on his successors. 'The Murders in the Rue Morgue' was one of the first detective stories ever written. Because of this, Edgar Allen Poe has set a trend for other detective writers to follow. Poe has used a number different of 'points' in his story to create suspense and tension, which can be found in other detective stories of that time. For example, in Dorothy L. Sayers writing about 'The Murders in the Rue Morgue', she writes that 'The story features a combination of three typical motifs. The wrongly suspected man . . . . the sealed death chamber and the solution by unexpected means.' These examples can all be found in most of Arthur Conan Doyle's 'Sherlock Holme... ...man who was murdered, Cadogen West, had taken the papers. In conclusion to this essay, we can see that throughout the stories that we have read, how often the writers have imitated Poe's original six points. We can see that the writers have imitated the classic six points quite well. Some of the stories might not contain all of the six points, but the points they do contain have all added to the creation of suspense and tension in the mind of the reader. All of the writers we have looked at, in one way or another, have all tried, and successfully incorporated the basic character of Dupin into their own. It is evident that the most successful story that we have read has to be 'The Problem of Dressing Room A.' It has included all of the classic six points that Sayers mentioned about 'The Murders in the Rue Morgue' and the outrà © character of the detective.

Ponder the Meaning of Life With 1984 and The Matrix Essay example --

The film The Matrix, directed by Andy and Lana Wachowski, may seem to be a unique, original storyline to the untrained viewer, but the story of a totalitarian government and a hero who attempts to save the people is far from this. In reality, there are so many similarities that can be seen in other texts that were written and filmed before that it cannot be ignored. In particular, George Orwell’s 1984 has a similar government that controls its people and a â€Å"hero†, Winston, who is also searching for the truth. Winston lives Oceania where Big-Brother and â€Å"The Party† schedule your entire lives telling when to sleep, eat, and work and keep you under constant surveillance. This is similar in The Matrix, where most of the humans lived in a computer-programmed world which is also constantly surveyed by government authorities. The Wachowski siblings’ film, The Matrix, connects with the concept of dystopia as expressed in George Orwell’s novel, 198 4, by referring to a totalitarian government and the lack of choices, which it accomplishes through the introduction of new surveillance technology, comparing two worlds, and a hero’s journey to liberate the people. The use of new surveillance technology in both 1984 and The Matrix helps to make a world in which people are truly living under complete control believable. In The Matrix, it is possible to hack into the Matrix world, but the government is easily able to detect where the hack is happening and catch up to the hackers. One example in the film is when Neo goes with Morpheous and his crew back to the â€Å"Matrix† world and the government agents quickly catch up with them, breaks into their â€Å"warehouse†, and nearly stops them from leaving to go back to the real world. The government is an omn... ... point that the Wachowski’s are making: freedom and choices give life meaning. We can easily see how the Wachowski’s drew from similar ideas as Orwell in 1984, but has a more hopeful ending. Both texts use surveillance to show how the people are under complete control and show us a world where people believe the lies and are trapped in. The one major difference is that one text does not give us hope and belief that things can be changed, while the other one does. The Matrix does that latter. They give us hope by showing characters that live in a real world with freedoms and are happy. Neo’s life does have a meaning and a purpose. Without seeing the same conclusion in 1984, but with a depressing ending, one would not be able to see as clearly in The Matrix that having freedom and choices is what gives life meaning and we must strive to always keep our freedoms. Ponder the Meaning of Life With 1984 and The Matrix Essay example -- The film The Matrix, directed by Andy and Lana Wachowski, may seem to be a unique, original storyline to the untrained viewer, but the story of a totalitarian government and a hero who attempts to save the people is far from this. In reality, there are so many similarities that can be seen in other texts that were written and filmed before that it cannot be ignored. In particular, George Orwell’s 1984 has a similar government that controls its people and a â€Å"hero†, Winston, who is also searching for the truth. Winston lives Oceania where Big-Brother and â€Å"The Party† schedule your entire lives telling when to sleep, eat, and work and keep you under constant surveillance. This is similar in The Matrix, where most of the humans lived in a computer-programmed world which is also constantly surveyed by government authorities. The Wachowski siblings’ film, The Matrix, connects with the concept of dystopia as expressed in George Orwell’s novel, 198 4, by referring to a totalitarian government and the lack of choices, which it accomplishes through the introduction of new surveillance technology, comparing two worlds, and a hero’s journey to liberate the people. The use of new surveillance technology in both 1984 and The Matrix helps to make a world in which people are truly living under complete control believable. In The Matrix, it is possible to hack into the Matrix world, but the government is easily able to detect where the hack is happening and catch up to the hackers. One example in the film is when Neo goes with Morpheous and his crew back to the â€Å"Matrix† world and the government agents quickly catch up with them, breaks into their â€Å"warehouse†, and nearly stops them from leaving to go back to the real world. The government is an omn... ... point that the Wachowski’s are making: freedom and choices give life meaning. We can easily see how the Wachowski’s drew from similar ideas as Orwell in 1984, but has a more hopeful ending. Both texts use surveillance to show how the people are under complete control and show us a world where people believe the lies and are trapped in. The one major difference is that one text does not give us hope and belief that things can be changed, while the other one does. The Matrix does that latter. They give us hope by showing characters that live in a real world with freedoms and are happy. Neo’s life does have a meaning and a purpose. Without seeing the same conclusion in 1984, but with a depressing ending, one would not be able to see as clearly in The Matrix that having freedom and choices is what gives life meaning and we must strive to always keep our freedoms.

A Young Womans Fantasy in The Turn of the Screw Essay -- Henry James

A Young Woman's Fantasy in The Turn of the Screw   Ã‚  Ã‚   The Turn of the Screw, by Henry James, is an odd story about a young woman who, leaving her small country home for the first time, takes a job as a governess in a wealthy household.   Shortly after her arrival, she begins to suffer from insomnia and fancies that she sees ghosts roaming about the grounds.   James is a master story-teller and, at times, the complexities of the story make it difficult to follow.   The Turn of the Screw is a story within a story, the tale of the governess being read aloud as a ghost story among friends.   Harold C. Goddard wrote a fascinating piece of criticism entitled "A Pre Freudian Reading of The Turn of the Screw."   When applied to the book, his theory makes perfect sense.   Goddard suggests that the governess, young and inexperienced, immediately falls in love with her employer during their meeting.   As a result of her unrequited love, her overactive mind creates a fantasy in which the the two ghosts intend to harm the children, in order to make herself a heroine, thereby getting the attention of her employer.      Ã‚  Ã‚  Ã‚   Goddard points out that the young woman is unstable from the beginning.   We find out little about her background, except that she is "the youngest of several daughters of a poor country parson" (4).   It becomes immediately obvious to the reader that such a drastic change of environment as she experiences is cause enough for her to experience extreme anxiety.   Indeed, she tells Mrs. Grose, "I'm rather easily carried away.   I was carried away in London!" (8).   After her interview with her potential employer, the man from Harley Street and the uncle of her young charges, she goes on and on about the man, praising him and ... ... that haunt the grounds.   The story is told through the voice of the governess, which, considering her mental state, makes it difficult to decipher what is actually occurring.   There are many questions that are never answered, rather, they are left up to the reader to decide. Works Cited and Consulted Freud, Sigmund. An Outline of Psycho-Analysis. New York: W. W. Norton & Company, Inc., 1969. Goddard, Harold C. A Pre Freudian Reading of The Turn of the Screw. New York: Hillary House Publishers, 1960. James, Henry. "The Turn of the Screw". The Turn of the Screw and Other Short Novels. New York: New American Library, 1995. Nunning, Ansgar. "Unreliable Narrator." Encyclopedia of the Novel. Ed. Paul Schellinger. Chicago: Fitzroy Dearborn, 1998. 1386-1388. Wagenknecht, Edward. The Tales of Henry James. New York: Frederick Ungar Publishing Co., 1984. A Young Woman's Fantasy in The Turn of the Screw Essay -- Henry James A Young Woman's Fantasy in The Turn of the Screw   Ã‚  Ã‚   The Turn of the Screw, by Henry James, is an odd story about a young woman who, leaving her small country home for the first time, takes a job as a governess in a wealthy household.   Shortly after her arrival, she begins to suffer from insomnia and fancies that she sees ghosts roaming about the grounds.   James is a master story-teller and, at times, the complexities of the story make it difficult to follow.   The Turn of the Screw is a story within a story, the tale of the governess being read aloud as a ghost story among friends.   Harold C. Goddard wrote a fascinating piece of criticism entitled "A Pre Freudian Reading of The Turn of the Screw."   When applied to the book, his theory makes perfect sense.   Goddard suggests that the governess, young and inexperienced, immediately falls in love with her employer during their meeting.   As a result of her unrequited love, her overactive mind creates a fantasy in which the the two ghosts intend to harm the children, in order to make herself a heroine, thereby getting the attention of her employer.      Ã‚  Ã‚  Ã‚   Goddard points out that the young woman is unstable from the beginning.   We find out little about her background, except that she is "the youngest of several daughters of a poor country parson" (4).   It becomes immediately obvious to the reader that such a drastic change of environment as she experiences is cause enough for her to experience extreme anxiety.   Indeed, she tells Mrs. Grose, "I'm rather easily carried away.   I was carried away in London!" (8).   After her interview with her potential employer, the man from Harley Street and the uncle of her young charges, she goes on and on about the man, praising him and ... ... that haunt the grounds.   The story is told through the voice of the governess, which, considering her mental state, makes it difficult to decipher what is actually occurring.   There are many questions that are never answered, rather, they are left up to the reader to decide. Works Cited and Consulted Freud, Sigmund. An Outline of Psycho-Analysis. New York: W. W. Norton & Company, Inc., 1969. Goddard, Harold C. A Pre Freudian Reading of The Turn of the Screw. New York: Hillary House Publishers, 1960. James, Henry. "The Turn of the Screw". The Turn of the Screw and Other Short Novels. New York: New American Library, 1995. Nunning, Ansgar. "Unreliable Narrator." Encyclopedia of the Novel. Ed. Paul Schellinger. Chicago: Fitzroy Dearborn, 1998. 1386-1388. Wagenknecht, Edward. The Tales of Henry James. New York: Frederick Ungar Publishing Co., 1984.

The Beach Descriptive Essay.

Ddirk Mrs. K English 9 A October 24, 2012 Descriptive Essay The look of glee on people faces is the look that you might expect from a child on Christmas day. Why this look? They are on the most amazing place on earth truly it’s a gift from God Himself the â€Å"beach†. The beach is a quiet and peaceful place but at the same time it can be so noisy because the number of people that are on this beach is as if the new iphone 5 is being sold. You just have to allow yourself to become that carefree kid again and let go.As I look out to sea I hear and see the waves crashing down so eager to get to the shore line and I think how can something so beautiful be so deadly at the same time? I am completely unaware of my surroundings as I am lost deep in thought. I hear nothing. Then I am taken aback by the sound of a child’s pure laughter a sound that you would only expect to hear from a child but wait! It’s not a sound of one child laughter it’s a sound of a w hole family completely care free and undaunted by the problem they have, for now the biggest problem they have is who’s sand castle is the best.All they want to do is enjoy these memories in the making and have fun. If you are not careful you might let go of you worries and fear and become a child again. On this sunny beach the hot sand is messed up from people walking on it, making sand castles, hand prints from little kids who are so eager to get themselves messy and my personal favorite foot prints in the sand from big and little kids all alike. I look at the sand as I am walking and I realize just how many sand dollars, seashells and rocks are hidden in the sand just barely visual to a wandering eye.It is like they are playing a game of peek-a-boo with you, not wanting to be caught but also not wanting to be unaware of their surroundings. As I reach out to pick up neat sand dollars that are hairy it’s almost like you are picking up a spider or something that is gro ss, seashells that are so cold that you would think they had been in the freezer, rocks that are so flat and smooth its unreal, and drift wood that is so smooth you don’t get splinters. The sound of seagulls squawking is so loud that you think that you might go crazy if you ere another one squawk again, yet this apart of the beauty of the beach and they too are an amazing part of the beach. Yum†¦ the smell of the beach goes from smelling like a fish hatchery, to the smell of people cooking food on the grill and then you suddenly realize you too are hungry. Its lunch time and it’s time to try to get the sand that is inevitable off of you. I walk into the water unaware that the water is as cold as ice the water reaches my toes first and my instant reaction is to scream.I scream and run out and I am greeted with the stares from the on goers I am instantly embarrassed and suddenly feel like everybody on the beach is staring at me and is wondering what is wrong with th at girl? I should have known that the water would be cold because it’s always cold what was I thinking? I guess I was still in awe of the beauty of the beach I think to myself I will and will never get tired of this amazing and beautiful place for as long as I live. It has been I long day and I am exhausted from such a long day of fun.As the wind on my face is like a fan blowing directly in front of me, cooling of the beach and the people from the heat. I think to myself what makes the beach wonderful is the sound of children’s laughter, the squawking of those annoying seagulls, the smell of the fish hatchery, the grainy feeling of the sand that always seems to get into your mouth no matter what, the smell and the taste of the salty water that you swallow and just the smell of outdoors and wood burning.Those are the things that make up a beach; without those things it would not be near as exciting. As I watch the sunset I realize that the worries of the real world may sometimes not allow a person to become a child again and how sad to think they are on an amazing place with so much beauty which you should be carefree and they can’t because they are not able to let go. I love the beach! I believe it was and is a blessing from God.

Life of Pi Existentialist Examination

Is Life of Pi Existentialist? There are two views of existentialism, that of the more popular atheistic view, and that of the theistic view (Sartre Lecture). In the book Life of Pi, by Yann Martel the main theme of the book is religion, with the main character being of multiple religions: Hinduism, Christian Catholicism, and Islam. (Martel). Life of Pi is both Existentialist and non-existentialist, in both the atheistic and theistic views because of specific religious beliefs, abandonment of religion, despair, and the ultimate use of human instinct for survival.I would first like to begin by giving brief explanations of both sides of existentialism, because both do apply to this book, even though the main theme is religion. The main idea of existentialism is that of â€Å"existence before essence† (Sartre Lecture). By this, they mean that we define ourselves as what we are by our own actions and free will. We exist before our essence, or our determined character, because we de termine it for ourselves by our own doings. â€Å"In the book Life of Pi, by Yann Martel the main theme of the book is religion.The theistic view of existentialism can basically be summed up by this quote: â€Å"When we think of God as the creator, we are thinking of him, most of the time, as a supernal artisan† (Sartre Lecture). By this, they mean that theists view god as the all powerful creator. He created man with a specific idea in mind, and he knew what we would do and create. â€Å"God creates he knows precisely what he is creating† (Sartre, Lecture. ) He knows the past, present, and future, and will not allow us to be defined by our human nature.Human nature was simply a side effect, to allow us to understand possibly why and how we are, but we can’t let it define ourselves as humans. Our intellect and creations define us as who we are, not our natural instinct. Therefore, we cannot blame something on instinct and human nature, because god did not creat e us to do that. He created us to innovate. And as intellectuals, it is our job to realize what we are here for, and to fulfill god and ourselves as human and not to let petty biological needs hinder our knowledge.It is our job to differentiate ourselves from one another, because we all have the same human nature and basic needs, and if we did not use our minds to create an image for ourselves, we would all be the same. On the other hand, the atheistic view, â€Å"Atheistic existentialism, declares with greater consistency that if God does not exist there is at least one being whose existence comes before its essence, a being which exists before it can be defined by any conception of it. That being is man or the human reality† (Sartre Lecture).This is saying that there is no human nature, because there was no god to conceive humans, or the idea of human nature. Man just simply is, and there is no meaning to life or existence unless they give meaning to it. They decide who the y are and who they want to be, or if they are anything at all, and there is no god to have decided what humans will be because he does not exist himself. â€Å"Man will only attain existence when he is what he purposes to be. Not, however, what he may wish to be† (Sartre Lecture).Man does not have existence unless he creates it for himself, therefore counteraction the theistic view, and saying that essence is before existence. Your essence allows you to exist. Within Life of Pi, there are many things that point to it being possibly theistically existentialist. For example, one of the three religions he believes in is Hinduism, which the aspect of reincarnation and karma are greatly important in. Reincarnation is the belief that your soul is passed down through many physical forms, and karma determines what physical form your soul will take on in the next life.This follows with existentialism because it is the thought that you are not tied down by your physical attributes, but you are defined by what you do in life and what image you create for yourself, and gods ultimately decide what physical form you will take on. Therefore, you cannot be defined by what physical form you have or human instinctual needs. It is your job to see beyond that. Another thing that Pi does that coincides with theistic existentialism is that of when he is abandoned on the boat, he still continues to pray five times a day (Martel).Yes, other actions that he committed on the boat proved otherwise to be non-existential, but he remained hopeful by praying on the boat for quite a while, feeling that he was not yet abandoned by god and did not completely succumb to his human needs and solely focusing on survival. Moving on to ways that the book is non-existentialist, I believe that the book was far more non-existentialist from the theistic view. One of the ways was how Pi was the denomination of Catholicism (Martel), which is a denomination of Christianity that does not believe in f ree will.They believe that free will is a denial of grace, or the denial that God created humans in the image of himself, which is pretty much the exact opposite of existentialism itself. Existentialists believe that god gave man the power of free will because he knows what they will do with their free will, and there is no denial of the image of god. Another way that Life of Pi is not existentialist is when he is on the boat, and commits acts of human instinctual survival. He goes against his beliefs to survive.An example of that is when he goes against his vegetarianism and love of animals to drink the turtles blood (Martel). This is abandoning your beliefs and self image to survive, and just giving into human instinct, which brings me to another topic of atheistic existentialism: anguish, abandonment, and despair (Sartre Lecture). â€Å"Anguish† is basically describing that, when a man decides for himself, he is not only deciding something for himself, but that of all mank ind because he is representing them all as a whole because all of our decisions define us (Sartre Lecture). Abandonment† is saying that we cannot depend on god to give us moral guidance. We have to have our own moral, and not look to god and holy books to decide what we do in life (Sartre Lecture). â€Å"Despair† basically means that there should be no despair, because there is no limit as to what we can do. If there is no god, there is no all-powerful being, and then there is no one to decide our limits for us. Therefore, we cannot be in despair, for the possibilities are endless (Sartre Lecture). They all seem to counteract the belief in god, so in the atheistic sense, Life of Pi isn’t existentialist at all.He became a bit absorbed with himself, and not mankind while he was on the boat. He did not care about the animal he killed, and went with human instinct, thus only caring about himself. He depended on his multiple gods for guidance, and also expected them t o help him while keeping up with prayer five times a day (Martel). In conclusion, I believe that Life of Pi is non-existentialist as a whole. Too many things point to it being non-existentialist in the theist sense, and pretty much all things point to it being non-existentialist in the atheist view.Reincarnation and Karma seem to coincide with that of existentialism, as well of his perseverance with faith. But that same perseverance counteracts that of the atheistic view, with anguish, abandonment, and despair. He also showed true human instinct by going against his instincts to survive. I believe that the non-existentialist aspects definitely outweigh the existentialist ones. Works Cited Martel, Yann. Life of Pi. Orlando: Harcourt, Inc. , 2001. Print. Sartre, Jean Paul. Philip Mairet, trans. â€Å"Existentialism is a Humanism. † Lecture given in 1946. Web. 11 December 2012.

Mattel Toy Recall Essay

1. What are the main issues involved in the case? Mattel had five recalls in 2007 involving over 21 million toys. The problems were related to lead paint and poorly designed magnets. Most of the toys were made in China, which caused them to question the reliability of the Chinese manufacturers. At first, Mattel tried to put all the blame on the Chinese manufacturers as a denial tactic. They also claimed the media and government overly magnified the crisis. Mattel also failed to notify the CPSC of the defects within the time limit of 24 hours. It took them nearly a month and a half to notify the CPSC. Even though the recalls were in 2007, there were incidents/injuries reported in 2003 with children needing surgery because of the toy defects. One death was recorded. 2. Identify the major stakeholders and state how the issues in the case affect each stakeholder. Competitors: Because Mattel is such a large and trusted company that outsources, customers were nervous to trust other companies that outsourced. Who was to say they did not have the same issues as Mattel? Investors: Stocks dropped and investors lost money. They ended up suing based on allegations of failure to disclose recalls in a timely manner, and failure to have proper protocols to avoid recalls. Customers: Many children were injured and required surgery, and one child even died. Parents lost faith in Mattel and created lawsuits against them. Employees: Because of the accusations on the Chinese manufacturers, job security in China all but diminished. Job security and pay decreased in America too because of the fines from the CPSC, and the cost of the recalls. 3. How could this case be viewed from an ethical perspective? It was Mattel’s job to report the incident in a specific time limit, which they failed to do. They could have warned parents approximately a month and a half earlier, possibly saving children from painful injuries and surgeries. Mattel also put the blame on the Chinese and did not own up to their own mistakes. 4. What final conclusions or recommendations would you draw? Immediately tackle any issues or problems that arise to avoid a larger fiasco. Implement higher standards and checks to ensure the safety of the products. Follow all government statues and be sure that the outsource countries have the same or similar regulations and priorities that we hold.

French Educational System Compared to the American System Essay

France and the United States have numerous striking differences and tastes in almost all cultural aspects. The French education system has been criticized globally by scholars and experts in various career fields for its failure to provide a flexible, all-round education. However, it has also received praise and recognition by the world at large for its significant contribution to the field of mathematics, with the revolution in banking in the late 20th century pioneered by French mathematicians. The United States education system, on the other hand, is increasingly receiving favor by international students for its provision of high class, market friendly education, despite the current criticism on the high cost of education. This paper compares the French and the American education systems. There are many differences, as well as similarities, in the French and the US education systems. One of the major aspects which have raised concern is on higher education. In both countries, higher education is given high priority, and in the US, for instance, the majority of adults are college educated. In France, higher education is also highly valued, with a person’s popularity and respect increasing as she or he advances in education. A significant difference in the higher education in both France and the US, however, is on the entrance process to university. In the French education system, before one can gain access to university studies, the final exam, the Baccalaureat, or the â€Å"Bac† is mandatory. The â€Å"Bac† is a rigorous school-leaving examination with no multiple choice questions and includes a written part and an oral part, with several subjects each. The â€Å"Bac† is highly valued in the nation so much that despite numerous criticisms from scholars globally to change the system and implement other selection methods, the nation has refused to change it. (Understandfrance. org, 2008) Despite the tough examination system, the French have no other university selection method. The nationwide â€Å"no selection† policy has raised controversy from scholars worldwide who find the method not sufficient for a thorough process. College selection in the US however, is very vigorous and students undergo numerous processes before gaining entrance to college. Selection is comprised of practices such as writing a personal statement, attending an interview, being involved in extra curricular activities among of course, the class ranking and the grades earned in high school courses taken. Recommendations too, by responsible persons are also considered before one can gain entrance into any higher institution of learning. A major reason which has made many international students prefer the higher education system in the United States over that in France in the recent past is the many facilities and services offered in US institutions. Issues such as overcrowding in lecture halls, for instance, are not experienced in majority of US institutions, although quite evident in most of the universities in France. Such prestige, however, comes at a cost. College tuition fees in the US can in no way be comparable to France, where education, interestingly, at all levels is almost free and only 26 percent of university students receive scholarships. (Understandfrance. org, 2008) Tuition fees is so high in the US, such that scholarships alone cannot cater for the students; the majority of US students receive either loans, grants or both from the government, so as to cater for their tuition fees. The government, in fact cannot sufficiently cater for the tuition needs of all the students, and private sources are increasingly becoming normal. Grants and loans are even not enough, and many students opt to sign up to study over the internet, in the many obviously questionable free online courses. Another striking difference in the education systems of both France and the United States is their curriculum. The French curriculum has been criticized globally for its failure to connect to the world market. Many demonstrations have been staged by French students, for decades and although there have been reforms; the reforms have not been good enough to cater for the current market demand. The US system, on the other hand, has diverse and flexible curricula, with a wide range of topics, from nuclear science to dance. As opposed to the French curricula, where extra curricular activities such as sports, musical groups and numerous clubs are not recognized in the curricula and where one can only have private classes for the same, in the US, such activities are given high priority. They can also be found in US institutions, both public and private. The flexibility of the US education system is what has made it the most preferred by international students worldwide, since they can have access to almost all interested areas of study. Unemployment, as a result is not as prevalent in the US as it is in France, with the recent demonstrations by French students to find solutions to the problem. The French are recognized as a literacy community, where education levels determine a person’s status. The more one advances in education, the more recognized she or he gets. This is a belief not common in the US. This general belief is what makes the education valued so greatly, with most French students spending most of their time in classroom related activities, allowing no room for other activities such as music and art related fields. Highly educated people in France in especially the globally viewed â€Å"tough† subjects such as mathematics, are given great respect, with the not very successful in education, despite their circumstances or other achievements, looked down upon and not recognized. In the United States, however, education levels are not given such respect and other issues such as healthcare are given more weight even politically. It is not surprising to note that the richest Americans are college dropouts, big names such as William Gates III. This notwithstanding, the education facilities in the United states are the best compared to other institutions worldwide. Despite critics arguing that French schools tend to make students theoretical and uncreative, French academic standards are high and discipline is strict. This is however not the case in the American education system, where the use of drugs is common especially in junior high and high schools. This problem has remained a major problem in the US for many years. (Hall, 1990, 99-102 & 144) Education, over the years, has played a very important role in the development of individuals and a nation. It is important to note that both the French and American education systems should be improved, in certain features, as aforementioned, such as eradicating the drug use in US schools, making the French system more market friendly and more relevant to the current market stage, and improving the overcrowded high education institutions. This move would in the long run, make both of the systems stronger, hence ensuring effectiveness in both; an important catalyst in the road to globalization. Works Cited: Hall M. R. (1990) Understanding Cultural Differences: Germans, French and Americans (Intercultural Press) Understandfrance. org (2008): Education in France. Retrieved December 2nd 2008 from: http://www. understandfrance. org/France/Education. html

Management accounting-Bias Budgets Coursework Example | Topics and Well Written Essays - 2000 words

Management accounting-Bias Budgets - Coursework Example Question One (a): Why do managers want to manipulate their budgets? After budget approval, the company may use it to carry out budgetary actions. As a result, the managers use it to ensure they carry out the organization objectives and plans and in the end, they have to compare budget plan against the real performance. Once compared, the difference in amount is usually the budget deficient or bias which is cause by manager`s manipulation or distortion on the proposed budget. There are various reasons as to why mangers manipulate budget. Firstly, if the rewards and motivation through performance evaluation help to achieve the budget results, the managers may end up manipulating the budget to include more of rewards in order they can hit the target more easily like league table and bonuses. Besides, managers are highly involved in cases of budget slacks-where organization set their revenue to be too low and a high cost, the organization may end up losing sales since the resources requi red to raise production with the short time given have been limited. Moreover, the managers who have been promised some rewards on attaining certain goals set their target to be very low such that they easily attain them without caring whether the company looses or gains. Likewise, the senior managers dictate on a budget for performance. As a result, it forces the mangers to keep focus of resources on the performance of their department. Consequently, the mangers end up presenting a budget request biased on his department not for organization as whole. Hence, the direction of bias is downwards. Secondly, the company`s practices and norms is subtle in determining the performance of the company`s budget. Notably, prevailing work conditions help to dictate what is morally right. As a result, the management, which focuses on self-manager performances, will give incentives directed to managers alone. However, the aggregate accounting performance from his action is focusing on organizatio n as whole. On the other hand, the management focusing on others gives a hard determination of degree of performance. As a result, it reduces the aggregate performance although it induces co-operation and collaboration to other firms. Moreover, when there occurs some change in the budgetary system from being top-down or centralized, and an acceptable estimate of growth is set, with the changing budgetary system to may be bottom up, and company`s practices remaining similar, bias of unknown direction happens. Lastly, the mangers may feel insecure in their job and as a result, they are more than ready to use the budgetary trick when a chance arises. By this, it mean, the managers are quick to spend until the entire budgeted amount is consumed when the chance of buying goods occurs at a lower price. In fact, in the managers operating in the declining sales department makes use of entire budgets usage under the assumption that the future is uncertain. As a result, the budget becomes was teful at the expense of the manager approving his need of upholding the job since the amount needed by the company and the bought one is very varying. Hence, strong upward bias occurs. (b): Why are they able to do? What are the constraints on such behaviour? As a long as the departmental budget exists, some head of the department will always try to game the budget. Additionally, there are numerous reason as

Cultural Awareness on Iran Research Paper Example | Topics and Well Written Essays - 1750 words

Cultural Awareness on Iran - Research Paper Example Iran possesses a unique culture that traverses across several elements. Culture is an aspect that achieves definition from different entities. Iranian culture belongs to the larger Persian identity that defines most countries in the same region. Persian culture forms one of the richest compositions in the world. This relates to literature, architecture and live customs that date back to three thousand years ago in the Zoroastrian age. Throughout civilization, this culture transferred to the eastern and western nations. It is notable that many western celebrations achieve their articulation from Persian culture. Art is an imminent feature of Persian culture. Art and culture interweave to form a prominent civilization. This reveals in the form of exquisite carpets, distinct architecture, subtle soulful music, blue mosques and brilliant literary work. Notably, Farsi forms one of the richest languages in the world. ... Bakhtiaris and Lurs speak the Luri dialect. There are semi nomadic people who speak the Baluchi language. They live in the adjacent areas, of Pakistan and Afghanistan, in the southeastern Iran. Twenty eight percent, of the Iranians, speak various Turkish dialects. Arabs and Assyrians mostly speak Semitic languages. Islam defines the core of Iranian culture and life. Islam forms the religion that governs political economic, legal and personal lives of Iran. In this aspect, Prophet Muhammad is the last God emissary that brought revelation to mankind. Islam provides that this message belongs to the whole of mankind. As in the example, of the Bible, Quran is the basic guidance of their religious life. Unlike the provision of the Bible, Quran strongly dictates many aspects of Iranian lives. Muslims have notable obligations such as praying five times a day. Friday forms a holy day in the Muslim worship calendar. Islam is an influential religion that dictates closure of companies on Thursda ys. In the holy month, of Ramadan, all Muslims are mandated to fast. Notably, Iran forms the only Shi’ite state of all the Muslim countries. Sunnis believe that the successive leadership of the Muslims did not have to come from the Prophet Muhammad family. The Shi’ite believes that the Islam leadership should have been monarchial. Iran and Iraq possess the highest population of Shi’ites. In terms of family values, the family forms the core social unit. In an Iranian setting, a family forms a very private unit. This is a distinct aspect whereby female relatives face protection from outside influences. A clear manifestation, of this cultural aspect, pertains to the taboo of asking a question about female relatives and someone’s life.

Shakespeare Comedies Term Paper Example | Topics and Well Written Essays - 2250 words

Shakespeare Comedies - Term Paper Example nd the critics declared his comedy as the most refined pieces of art and literature, even Aristotle has stated comedy as a mean form of the imitation of real life. But it is not applied to Shakespearean comedies, which serve as the guiding star for the future generations to come. Shakespeare does not take comedy as the ridiculous or ugly form of literature. On the contrary, he introduced new and novel elements in comedy that maintain theme, meanings and objectives within their fold. His plays under study also concentrate upon highlighting the follies and shortcomings human nature contains, and Shakespeare looks for addressing those follies and weaknesses in a sophisticated manner. Answer A: Though Shakespeare appears to be influenced by classical literature in his early comedies, yet he outgrows this impression in his future works. The same is applied by going through his â€Å"Taming of the Shrew† and Measure for Measure†, where he exercises his intellect while creating the city comedy in an innovative way without seeking inspiration from classicism. It has been the tradition of the playwrights to either classical or romantic genre while producing comedy and Shakespeare’s can be attributed as romantic in composition and decorum. He presents vivacious city life in both his comedies under study, where there is energy, light, vigor, thrill and passion where dancing, feasting, love-making, engagements, drinks and dinners and merry-seeking decorate the entire atmosphere, and the reader finds himself in an extremely pageant environment where there is peace, harmony, jubilance, excitement and pleasure all around. The same can be detected in the streets of Padua, where the characters offer, stipulate and exchange ecstasy, joys and delight, as Christopher Sly states while conversing with the hostess at the bar: â€Å"Ye are a baggage: the Slys are no rogues; look in the chronicles; we came in with Richard Conqueror. Therefore paucas pallabris; let the world slide:

Wittig reaction Essay Example | Topics and Well Written Essays - 1500 words

Wittig reaction - Essay Example The latter chemical agent is commonly known as the witting reagent, it results into chemical agents known as alkene as well as triphenylphosphine oxide (Carrutthers, 1971). Discovered in 1954 by Georg Witting, it continues to be vastly used in the organic synthesis of alkene preparation. This procedure should not be misunderstood with, the Witting rearrangement chemical procedure which is based on a different theory. The witting reaction is normally applicable in the coupling of aldehydes and kentones, is the single substitution of phosphine ylides. The out coming data from the ylides test results is nearly exclusive with the z-alkene chemical agent product. As such for one to obtain the E-alkene chemical agent, there is need to apply ylides under stabilization which can also be substituted with unstablised ylides. This can be undertaken with the application of the Schlosser modification chemical tests, after which the Witting reaction chemical test can be performed (Vedejs et al, 20 00). The witting reaction has a variation known as the classical mechanism; this is the established theoratical procedure of the witting reaction chemical test. It involves the bulk steric of ylide, this interacts with sterochemicals to produce nucleophilic addittives. This gives rise to betaine, the carbon-carbon bond rotation produces betaine tht in turn produces oxaphosphetane. By eliminating the desireable z-alkene in addittion to triphenylphosphine oxide components, the simplified witting reagents are used in a sequenced procedure. The first sequence of this procedure begins with a combination of aldehyes and ketones, this is followed by the decomposition of betaine. This decomposition occurs to the fifth form, this stage is also known as the rate-determination level. However, with ylides under stablization the initial sequence is noticed to be the slowest. As such the general alkene formation rate is reduced with time, this results into a sizeable proportion of the akene produ ct in which case being the E-isomer. This creates an understanding of the reasons, behind the failure of the stablizing reagents in proper reaction with sterical hindered ketones (Vedejs et al. 2000). Witting reagents such as phosphorus ylides, are prepared in a formulated procedure. Phosphium salt is the known derivative of preparation; it is also a resulting chemical agent from the reaction of triphenylphosphine and alkyl halide. As such in order to create the witting reagent being ylide, phosphonium salt must undergo suspension in a solvent such like diethyl ether with treatment of strong base chemicals like phenyllithium which can also be substituted with butyllitium. This can be shown with the following chemical equation Ph3P+CH2R X? + C4H9Li > Ph3P=CH?R + LiX + C4H10, in this chemical procedure methylenetriphenylphosphorane is the simplified ylide in use (Vedejs and Marth, 1998). This yield is also a precursor to a more defined elaboration of the witting reagents, alkylation o ccurs as seen in this chemical equation Ph3P=CH2 by the main alkyl halide that creates a phosphonium salt substitution. The formulation of these salts, is deprotonated in the normal matter resulting into a chemical agent as identified by the following chemical equation Ph3P=CH?CH2R. The ylide which is the witting reagent is structured in such a way that is identified as phosphorane in written form. This is an established representation of the ylide form, being a vital contributor as carbon remains mildly nucleophilic. Its chemical structure is comprised of a ball-and-stick model arrangement, that is takes the physical form of a crystal structure. In terms of its reactivity, simplified phosphoranes are highly reactive and very unstable in